-Major systemic disease -Age inappropriateness (70 years of age) -Cancer in the last 5 years except localized skin (not melanoma) or stage I breast or prostate -Active smoker (less than 6 months since quitting) -Active substance abuse -HIV -Severe local or systemic infection -Severe neurological deficits -Major psychiatric illness or active substance abuse that cannot be managed sufficiently to allow post-transplant care and safety
